3-異丁基-1-甲基黃嘌呤

3-Isobutyl-1-methylxanthine

MI5879-100mg   350.00

≥99% (HPLC), powder

別名: 1-甲基-3-異丁基黃嘌呤, 3,7-二氫-1-甲基-3-(2-甲基丙基)-1H-嘌呤-2,6-二酮, 3-異丁基-1-甲基-2,6(1H,3H)-嘌呤二酮, IBMX

· CAS號 28822-58-4 

· 經(jīng)驗分子式（希爾表示法） C₁₀H₁₄N₄O₂ 

· 分子量 222.24

· solubility  :DMSO: 1 M (with gentle warming)、ethanol: 10 mg/mL

storage temp.  ?20°C

產(chǎn)品描述

General description

3-isobutyl-1-methylxanthine/IBMX is a nonselective inhibitor.IBMX can induce melanogenesis. Hence, it is considered as a positive control in melanogenesis studies.

Application

3-Isobutyl-1-methylxanthine has been used:
? in the differentiation of mesenchymal stem cells (MSC)
? in adipogenic differentiation
? in glucose-stimulated insulin secretion test (GSIS)
? in the characterization of adipose-derived mesenchymal stem cells
? cAMP assay

3-Isobutyl-1-methylxanthine has been used:
? in the differentiation of mesenchymal stem cells (MSC)
? as a culture medium supplement for inducing adipogenic differentiation
? as a supplement in Krebs-Ringer buffer with HEPES (KRBH) solution for inducing glucose-stimulated insulin secretion (GSIS)
? in the characterization of adipose-derived mesenchymal stem cells
? in cyclic adenosine monophosphate (cAMP) assay
? in phosphodiesterase (PDE) inhibition

Biochem/physiol Actions

cAMP和cGMP磷酸二酯酶的非特異性抑制劑。由IBMX對磷酸二酯酶的抑制而引起的cAMP水平的增加可激活PKA，而引起增殖減少、分化增加并誘導(dǎo)細(xì)胞凋亡。 IBMX可抑制苯腎上腺素誘導(dǎo)的氣道粘膜神經(jīng)內(nèi)  分 泌上皮細(xì)胞5-羥色胺釋放。（IC₅₀：1.3 μM）。還可作為一種腺苷受體拮抗劑。 已顯示出對神經(jīng)肌肉接頭、GH3細(xì)胞和血管平滑肌細(xì)胞中離子通道的抑制。誘導(dǎo)感覺神經(jīng)元中儲存在細(xì)胞內(nèi)的鈣的釋放。