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Darinaparsin

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產(chǎn)品名稱: Darinaparsin
產(chǎn)品型號: MD819869
產(chǎn)品展商: 晶欣生物
產(chǎn)品文檔: 無相關(guān)文檔

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Darinaparsin 

Cat.Not：MD819869  

prices：5MG 1800 

           10MG 2800

Speciication


Darinaparsin is a dimethylated arsenic linked to glutathione. It is cytotoxic to DU145, LNCaP, and PC3 prostate cancer cells (IC50s = 5-10 &#181M) and patient-derived primary prostate cancer cells (IC50s = 2.5-20 &#181M), as well as Jurkat T cell lymphoma and L540 Hodgkin lymphoma cells (IC50s = 2.7 and 1.3 &#181M, respectively). [1][2] It decreases the tumor-initiating subpopulation in DU145 and PC3 cells and halts the cell cycle in the G2/M phase. Darinaparsin decreases transcription of Gli-2, a transcription factor that mediates Sonic hedgehog signaling, when used at a concentration of 1.5 but not 3 &#181M. It decreases SHP1 phosphatase activity and increases ERK phosphorylation. [2] Darinaparsin reduces tumor growth in DU145 and PC3 prostate cancer mouse xenograft models when administered at a dose of 100 mg/kg every other day.[1]



Chemical Properties

Cas No.

69819-86-9

SDF

 

別名

Dimethylarsinic glutathione

化學名

L-γ-glutamyl-S-(dimethylarsino)-L-cysteinyl-glycine

Canonical SMILES

OC(CNC([C@H](CS[As](C)C)NC(CC[C@H](N)C(O)=O)=O)=O)=O

分子式

C12H22AsN3O6S

分子量

411.3

溶解度

0.1mg/mL in ethanol and DMF, 10mg/mL in DMSO

儲存條件

Store at -20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Chemical Structure

                                    


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